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GLP 1 Pipeline Update: August 2025 Prime Therapeutics Portal Retatrutide GLP 1R GIPR GCGR ligand Sterile CAS2381089 83 2 CONS: Gastrointestinal side effects: Nausea, vomiting, diarrhea, and constipation affect approximately 50 60% of patients, especially during initial treatment. Muscle loss: Up to 39% of weight lost may come from lean The Pros and Cons of GLP Medications for Weight Optimization InHealthRVA GLP 1s and the Future of Workforce
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